THE DINMAN LABORATORY

Dahal B, Lin SC, Carey BD, Jacobs JL, Dinman JD, van Hoek ML, Adams AA, Kehn-Hall K. 2020. 
EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death. Virology 539:121-128.

Sulima, S.O. and Dinman, J.D. 2019. The expanding riboverse. Cells, 8(10). pii: E1205. 

Dinman, J.D. 2019. Slippery ribosomes perfer shapeshifting mRNAs. Proc Natl Acad Sci U S A., 116:19225-19227.

Dinman, J.D. 2019. Translational recoding signals: expanding the synthetic biology toolbox. J. Biol. Chem. 294: 7537-7545.

Dinman, J.D. 2019. Scaring ribosomes shiftless.  2019. Biochemistry. 58: 1831-1832. 

Haag, E.S. and Dinman, J.D. 2019. Still searching for specialized ribosomes. 2019. Developmental Cell. 48: 744-746. 

Sulima, S.O., Kampen, K.R., Vereecke, S., Verbeeck, J., Dinman, J.D. and De Keersmaecker, K. Ribosomal lesions as promoters of oncogenic mutagenesis. 2019. Cancer Research 79: 320-327

Dinman, J.D. Shapeshifting RNAs guide innate immunity.  J. Biol. Chem. 2018. J Biol Chem. 293:16125-16126.

Kendra JA, Advani VM, Chen B, Briggs JW, Zhu J, Bress HJ, Pathy SM, Dinman JD. Functional and structural characterization of the Chikungunya virus translational recoding signals. J Biol Chem. 293:17536-17545.

Dever, T., Dinman, J.D.,  and Green, R.. 2018. Chapter 4:  Translation Elongation, Recoding, and Quality Control in Eukaryotes. In: Translational Control in Biology and Medicine. Sonenberg, Hershey, and Matthews, eds. Cold Spring Harbor Laboratory Press. 

Chen B, Longhini AP, Nußbaumer F, Kreutz C, Dinman JD, Dayie TK. 2018. Chemistry 24:5462-5468. 

Briggs JW, Ren L, Chakrabarti KR, Tsai YC, Weissman AM, Hansen RJ, Gustafson DL, Khan YA, Dinman JD, Khanna C. PLoS One. 2017 12:e0185089. 

Sergey O. Sulima, Isabel J.F. Hofman, Kim De Keersmaecker, and Jonathan D. Dinman. How Ribosomes Translate Cancer.  Cancer Discovery 2017, 7: 1069-1068.

Tiziana Girardi, Stijn Vereecke, Sergey O. Sulima, Yousuf Khan, Laura Fancello, Joseph W. Briggs, Claire Schwab, Joyce Op de Beeck, Jelle Verbeeck, Jonathan Royaert, Ellen Geerdens, Carmen Vicente, Simon Bornschein, Christine J. Harrison, Jules P. Meijerink, Jan Cools, Jonathan D. Dinman, Kim R. Kampen, Kim De Keersmaecke. The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. Leukemia. 2018, 32: 809-819

Joseph W. Briggs and Jonathan D. Dinman. Subtractional Heterogeneity: A Crucial Step toward Defining Specialized Ribosomes. Mol Cell. 2017 Jul 6.

Suna P. Gulay, Sujal Bista, Amitabh Varshney, Serdal Kirmizialtin, Karissa Y. Sanbonmatsu and Jonathan D. Dinman. Tracking fluctuation hotspots on the yeast ribosome through the elongation cycle. Nucleic Acids Res. 2017, 45:4958-4971

Nahuel A. Paolini, Martin Attwood, Samuel B. Sondalle, Carolina Marques dos Santos Vieira, Anita M. van Adrichem, Franca M. di Summa, Marie-Franc¸oise O’Donohue, Pierre-Emmanuel Gleizes, Swaksha Rachuri, Joseph W. Briggs, Roman Fischer, Peter J. Ratcliffe, Marcin W. Wlodarski, Riekelt H. Houtkooper, Marieke von Lindern, Taco W. Kuijpers, Jonathan D. Dinman, Susan J. Baserga, Matthew E. Cockman and Alyson W. MacInnes. A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism. in Am J Hum Genet. 2017 Mar 2.

Sezen Meydan, Dorota Klepacki, Subbulakshmi Karthikeyan, Tõnu Margus, Paul Thomas, John E. Jones, Yousuf Khan, Joseph Briggs, Jonathan D. Dinman, Nora Vázquez-Laslop, Alexander S. Mankin. Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene. in Mol. Cell 2017 Jan 19.

Joseph A. Kendra, Cynthia de la Fuente, Ashwini Brahms, Caitlin Woodson, Todd M. Bell, Bin Chen, Yousuf A. Khan, Jonathan L. Jacobs, Kylene Kehn-Hall and Jonathan D. Dinman. Ablation of Programmed −1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. in J. of Virology 2017 Jan 18.

Christine Moomau, Sharmishtha Musalgaonkar, Yousuf A. Khan, John E. Jones, and Jonathan D. Dinman. Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA Elements. in J. Biol. Chem.  2016 Jul 22.

 Jonathan D. Dinman. Pathways to Specialized Ribosomes: The Brussels Lecture. in J. Mol. Biol.  2016 May 22.

Ivan Kisly, Suna P. Gulay, Uno Mäeorg, Jonathan D. Dinman, Jaanus Remme and Tiina Tamm. The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome. in J. Mol. Biol.  2016 May 20.

Justine Mailliot, Nicolas Garreau de Loubresse, Gulnara Yusupova , Arturas Meskauskas, Jonathan D. Dinman and Marat Yusupov. Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency in J. Mol. Biol.  2016 May 20.

Alan Baer, Lindsay Lundberg, Danielle Swales, Nicole Waybright, Chelsea Pinkham, Jonathan D. Dinman, Jonathan L. Jacobs and Kylene Kehn-Hall. Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. in J Virol 2016 Jan 20.

Vivek M. Advani and Jonathan D. Dinman, Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression. in BioEssays 2015 Dec. 12

 Alicia M Bowen, Sharmishtha Musalgaonkar, Christine A Moomau, Suna P Gulay, Mary Mirvis and Jonathan D Dinman. Ribosomal protein uS19 mutants reveal its role in coordinating ribosome structure and function. in Translation 2015 Nov 18.

Ashton T Belew & Jonathan D Dinman. Cell cycle control (and more) by programmed -1 ribosomal frameshifting: implications for disease and therapeutics. in Cell cycle 2015 Jan. 21

Kim De Keersmaecker1, Sergey O. Sulima and Jonathan D. Dinman . Ribosomopathies and the paradox of cellular hypo- to hyperproliferation. in Blood 2015 Jan. 7

Ali Dashti, Peter Schwander, Robert Langlois, Russell Fung, Wen Li, Ahmad Hosseinizadeh, Hstau Y. Liao, Jesper Pallesen, Gyanesh Sharma, Vera A. Stupina, Anne E. Simon, Jonathan D. Dinman, Joachim Frank and Abbas Ourmazd . Trajectories of the ribosome as a Brownian nanomachine. in PNAS 2014 Nov. 24

Jonathan D. Dinman. Molecular biology: Entry signals control development. in NATURE 2014 Nov. 19

Sharmishtha Musalgaonkar, Christine A. Moomau and Jonathan D. Dinman. Ribosomes in the balance: structural equilibrium ensures translational fidelity and proper gene expression. in NAR 2014 Nov. 11

Ashton Trey Belew, Arturas Meskauskas, Sharmishtha Musalgaonkar, Vivek M. Advani, Sergey O. Sulima, Wojciech K. Kasprzak, Bruce A. Shapiro and Jonathan D. Dinman. Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway in NATURE 2014 Jul. 9

Sergey O. Sulima, , Stephanie Patchett, Vivek M. Advani,Kim De Keersmaecker, Arlen W. Johnson and Jonathan D. Dinman. Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesisin Proceeding of National Academy of Sciences (PNAS) 2014 Mar. 6

Ban N1, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, Wilson D, Yonath A, Yusupov M. A new system for naming ribosomal proteins Curr. Opinion in Struc. Bio. 2014 Feb. 10

Michel de Messieres, Jen-Chien Chang, Ashton Trey Belew, Arturas Meskauskas, Jonathan D. Dinman and Arthur La Porta. Single-Molecule Measurements of the CCR5 mRNA Unfolding PathwaysBiophysical Journal 2014 Jan. 7

Sergey O. Sulima, Suna P. Gulay, Margarida Anjos, Stephanie Patchett, Arturas Meskauskas, Arlen W. Johnson and Jonathan D. Dinman. Eukaryotic rpL10 drives ribosomal rotation NAR 2013 Nov. 8

Feng Gao, Suna P. Gulay, Wojciech Kasprzak, Jonathan D.Dinman, Bruce A. Shapiro and Anne E. Simon The Kissing-Loop T-Shaped Structure Translational Enhancer of Pea Enation Mosaic Virus Can Bind Simultaneously to Ribosomes and a 5'Proximal Hairpin JVirol 2013 Aug. 08

Vivek M. Advani, Ashton T. Belew, Jonathan D. Dinman. Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway Translation 2013 Mar. 22

Ewan P. Plant, Amy C. Sims, Ralph S. Baric, Jonathan D. Dinman and Deborah R. Taylor Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production.Viruses 2013 Jan. 18

Daniella Ishimaru, Ewan P. Plant, Amy C. Sims, Boyd L. Yount Jr, Braden M. Roth, Nadukkudy V. Eldho, Gabriela C. Pérez-Alvarado, David W. Armbruster, Ralph S. Baric, Jonathan D. Dinman, Deborah R. Taylor and Mirko Hennig RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus. NAR 2012 Dec. 28

Dinman, Jonathan D. (Ed.) Biophysical approaches to translational control of gene expression. [BOOK] Biophysics for the Life Sciences, Vol. 1. ISBN 978-1-4614-3990-5 Sep. 2012.

Lasse Jenner, Sergey Melnikov, Nicolas Garreau de Loubresse, Adam Ben-Shem, Madina Iskakova, Alexandre Urzhumtsev, Arturas Meskauskas, Jonathan Dinman, Gulnara Yusupova, Marat YusupovCrystal Structure of 80S Yeast Ribosome. Current Opinion in Structural Biology (Elsevier) Sep. 2012.

Dinman JD. Mechanisms and implications of programmed translational frameshifting WIREs RNA 2012.Sep 2012.

Dinman JD. Control of gene expression by translational recoding. (Chapter) Adv.Protein.Chem.Struct.Biol. 2012 Jan.

Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD. rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol. Cell 2011 Nov 18.

Meskauskas A, Leshin JA, Dinman JD. Chromatographic Purification of Highly Active Yeast Ribosomes. JoVE 2011 Oct 24.

Guo R, Meskauskas A, Dinman JD, Simon AE. Evolution of a helper virus-derived, ribosome binding translational enhancer in an untranslated satellite RNA of Turnip crinkle virus. Virology. 2011 Oct 10.

Rhodin MH, Dinman JD. An extensive network of information flow through the B1b/c intersubunit bridge of the yeast ribosome. PLoS One. 2011 May 19.

Rakauskaite R, Liao PY, Rhodin MH, Lee K, Dinman JD. A rapid, inexpensive yeast-based dual-fluorescence assay of programmed--1 ribosomal frameshifting for high-throughput screening. NAR. 2011 May 20.

Leshin JA, Heselpoth R, Belew AT, Dinman JD. High throughput structural analysis of yeast ribosomes using hSHAPE. RNA Biol. 2011 May 1.

Rhodin MH, Rakauskaite R, Dinman JD. The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity. Mol Genet & Genomics. 2011 Apr 26.

Rakauskaite R, Dinman JD. Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes. RNA 2011 Mar 25.

Stupina VA, Yuan X, Meskauskas A, Dinman JD, Simon AE. Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virusosomal frameshift signals o JVirol. 2011 Mar 9.

Belew AT, Advani VM, Dinman JD. Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast. NAR. 2010 Nov 24.

Liao PY, Choi YS, Dinman JD, Lee KH. The many paths to frameshifting: kinetic modelling and analysis of the effects of different elongation steps on programmed -1 ribosomal frameshifting.NAR. 2010 Sept 7.

Rhodin MH, Dinman JD. A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding. NAR. 2010 Aug 12.

Meskauskas A, Dinman JD. A molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-site. NAR. 2010 Jul 21.

Leshin JA, Rakauskaite R, Dinman JD, Meskauskas A. Enhanced purity, activity and structural integrity of yeast ribosomes purified using a general chromatographic method. RNA Biol. 2010 May 22.

Plant EP, Rakauskaite R, Taylor DR, Dinman JD. Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins. J Virol. 2010 May 8.

Dinman JD, Kinzy TG. Expanding the ribosomal universe. Structure. 2009 Dec 9.

Dinman JD. The eukaryotic ribosome: current status and challenges. J. Biol Chem. 2009 May 1.

Meskauskas A, Dinman JD. Ribosomal protein L3 functions as a 'rocker switch' to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea. NAR. 2008 Oct 2.

Stupina VA, Meskauskas A, McCormack JC, Yingling YG, Shapiro BA, Dinman JD, Simon AE. The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits. RNA. 2008 Nov.

Petrov AN, Meskauskas A, Roshwalb SC, Dinman JD. Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit. NAR. 2008 Nov.

Belew AT, Hepler NL, Jacobs JL, Dinman JD. PRFdb: a database of computationally predicted eukaryotic programmed -1 ribosomal frameshift signals. BMC Genomics 2008 Jul.

Plant EP, Dinman JD. The role of programmed-1 ribosomal frameshifting in coronavirus propagation. Front Biosci. 2008 May.

Liao PY, Gupta P, Petrov AN, Dinman JD, Lee KH. A new kinetic model reveals the synergistic effect of E-, P- and A-sites on +1 ribosomal frameshifting. NAR. 2008 May.

Arturas Meskauskas, Johnathan R. Russ and Jonathan D. Dinman. Structure/function analysis of yeast ribosomal protein L2. NAR. 2008 Apr.

Rasa Rakauskaite and Jonathan D. Dinman. rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance. NAR. 2008 May

Stephen Swatkoski, Peter Gutierrez, Colin Wynne, Alexey Petrov, Jonathan D. Dinman, Nathan Edwards, and Catherine Fenselau. Evaluation of Microwave-Accelerated Residue-Specific Acid Cleavage for Proteomic Applications Proteome Res. 2008 Jan 12.

Chaudhuri S, Vyas K, Kapasi P, Komar AA, Dinman JD, Barik S, Mazumder B.. Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation. RNA. 2007 Oct 5.

Swatkoski S, Gutierrez P, Ginter J, Petrov A, Dinman JD, Edwards N, Fenselau C. Integration of Residue-Specific Acid Cleavage into Proteomic Workflows. J Proteome Res. 2007 Sep 29. 

Plant EP, Nguyen P, Russ JR, Pittman YR, Nguyen T, Quesinberry JT, Kinzy TG, Dinman JD. Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae. PLoS ONE. 2007 Jun 13;2(6):e517.

Meskauskas A, Dinman JD. Ribosomal protein L3: gatekeeper to the A site. Mol Cell. 2007 Mar 23;25(6):877-88.

Baxter-Roshek JL, Petrov AN, Dinman JD. Optimization of Ribosome Structure and Function by rRNA Base Modification. PLoS ONE. 2007 Jan 24;2:e174. 

Jacobs JL, Belew AT, Rakauskaite R, Dinman JD. Identification of functional, endogenous programmed -1 ribosomal frameshift signals in the genome of Saccharomyces cerevisiae NAR 2006 Dec7

Rakauskaite R, Dinman JD. An Arc of Unpaired "Hinge Bases" Facilitates Information Exchange among Functional Centers of the Ribosome. Mol Cell Biol. 2006 Dec;26(23):8992-9002.

Dinman JD. Programmed Ribosomal Frameshifting Goes beyond Viruses. Microbe. 2006 Nov;1(11):521-527.

Song H, Baxter-Roshek JL, Dinman JD, Vakharia VN. Efficient expression of the 15-kDa form of infectious pancreatic necrosis virus VP5 by suppression of a UGA codon. Virus Res. 2006 Dec;122(1-2):61-8.

Plant EP, Dinman JD. Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems. RNA. 2006 Apr;12(4):666-73.

Muldoon-Jacobs KL, Dinman JD. Specific effects of ribosome-tethered molecular chaperones on programmed -1 ribosomal frameshifting. Eukaryot Cell. 2006 Apr;5(4):762-70.

Meskauskas A, Petrov AN, Dinman JD. Identification of functionally important amino acids of ribosomal protein l3 by saturation mutagenesis. Mol Cell Biol. 2005 Dec;25(24):10863-74.

Kiparisov S, Petrov A, Meskauskas A, Sergiev PV, Dontsova OA, Dinman JD. Structural and functional analysis of 5S rRNA in Saccharomyces cerevisiae. Mol Genet Genomics. 2005 Jul 27;:1-13.

Dontsova OA and Dinman JD.5S rRNA: Structure and Function from Head to Toe. IJBS 2005 June 1(1): 2-7.    Html2pdf version    Figures

Plant EP, Perez-Alvarado GC, Jacobs JL, Mukhopadhyay B, Hennig M, Dinman JD. A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift Signal. PLoS Biol. 2005 May 17;3(6):e172.

Plant EP, Dinman JD. Torsional restraint: a new twist on frameshifting pseudoknots. NAR 2005 Mar 30;33(6):1825-33.

Jacobs JL, Dinman JD. Systematic analysis of bicistronic reporter assay data. NAR 2004 32(20):e160.

Harger JW, Dinman JD. Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough. RNA. 2004 Nov;10(11):1721-9.

Petrov A, Meskauskas A, and Dinman JD. Ribosomal Protein L3: Influence on Ribosome Structure and Function. RNA biology (1), 59-65 (2004).

Plant EP, Wang P, Jacobs JL and Dinman JD. A programmed –1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element. NAR (32), 784-790 (2004).

Meskauskas A, Harger JW, Muldoon Jacobs KL, Dinman JD. Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae. RNA (8), 982-992 (2003).

Harger JW, Dinman JD. An in vivo dual-luciferase assay system for studying translational recoding in the yeast Saccharomyces cerevisiae. RNA (8), 1019-1024 (2003).

Meskauskas,A., Baxter,J.L., Carr,E.A., Yasenchak,J., Gallagher,J.E., Baserga,S.J., and Dinman,J.D. Delayed rRNA processing results in significant ribosome biogenesis and functional defects. Mol. Cell Biol. 23, 1602-1613 (2003).

Plant, E.P., Muldoon Jacobs, K.L., Harger, J.W., Meskauskas, A., Jacobs, J.L., Baxter, J.L., Petrov, A.N., Dinman, J.D. The 9-Å solution: How mRNA pseudoknots promote efficient programmed -1 ribosomal frameshifting. RNA (9), 168-174 (2003).

Harger,J., Meskauskas,A. & Dinman,J. An 'integrated model' of programmed ribosomal frameshifting. Trends Biochem. Sci. 27, 448 (2002). [ COVER ]

Goss,K.T. et al. New targets for antivirals: the ribosomal a-site and the factors that interact with it. Virology 300, 60 (2002).

Dinman,J.D. et al. The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure. Proc. Natl. Acad. Sci. U. S. A 99, 5331-5336 (2002).

Smith,M.W., Meskauskas,A., Wang,P., Sergiev,P.V. & Dinman,J.D. Saturation mutagenesis of 5S rRNA in Saccharomyces cerevisiae. Mol. Cell Biol. 21, 8264-8275 (2001).

Meskauskas,A. & Dinman,J.D. Ribosomal protein L5 helps anchor peptidyl-tRNA to the P-site in Saccharomyces cerevisiae. RNA. 7, 1084-1096 (2001).

Harger,J.W., Meskauskas,A., Nielsen,J., Justice,M.C. & Dinman,J.D. Ty1 retrotransposition and programmed +1 ribosomal frameshifting require the integrity of the protein synthetic translocation step. Virology 286, 216-224 (2001).

Hudak,K.A., Hammell,A.B., Yasenchak,J., Tumer,N.E. & Dinman,J.D. A C-terminal deletion mutant of pokeweed antiviral protein inhibits programmed +1 ribosomal frameshifting and Ty1 retrotransposition without depurinating the sarcin/ricin loop of rRNA. Virology 279, 292-301 (2001).

Dinman,J., Ruiz-Echevarria,M., Wang,W. & Peltz,S. The case for the involvement of the Upf3p in programmed -1 ribosomal frameshifting. RNA. 6, 1685-1686 (2000).

Liermann,R.T., Dinman,J.D., Sylvers,L.A. & Jackson,J.C. Improved purification of the double-stranded RNA from killer strains of yeast. Biotechniques 28, 64-65 (2000).

Lopinski,J.D., Dinman,J.D. & Bruenn,J.A. Kinetics of ribosomal pausing during programmed -1 translational frameshifting. Mol. Cell Biol. 20, 1095-1103 (2000).

Cui,Y., Gonzalez,C.I., Kinzy,T.G., Dinman,J.D. & Peltz,S.W. Mutations in the MOF2/SUI1 gene affect both translation and nonsense- mediated mRNA decay. RNA. 5, 794-804 (1999).

Sheikh,M.S. et al. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). J. Biol. Chem. 274, 16487-16493 (1999).

Hammell,A.B., Taylor,R.C., Peltz,S.W. & Dinman,J.D. Identification of putative programmed -1 ribosomal frameshift signals in large DNA databases. Genome Res. 9, 417-427 (1999).

Hudak,K.A., Dinman,J.D. & Tumer,N.E. Pokeweed antiviral protein accesses ribosomes by binding to L3. J. Biol. Chem. 274, 3859-3864 (1999).

Peltz,S.W. et al. Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol. Cell Biol. 19, 384-391 (1999).

Ruiz-Echevarria,M.J., Yasenchak,J.M., Han,X., Dinman,J.D. & Peltz,S.W. The upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation. Proc. Natl. Acad. Sci. U. S. A 95, 8721-8726 (1998).

Dinman,J.D., Ruiz-Echevarria,M.J. & Peltz,S.W. Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents. Trends Biotechnol. 16, 190-196 (1998).

Cui,Y., Dinman,J.D., Kinzy,T.G. & Peltz,S.W. The Mof2/Sui1 protein is a general monitor of translational accuracy. Mol. Cell Biol. 18, 1506-1516 (1998).

Tumer,N.E., Parikh,B.A., Li,P. & Dinman,J.D. The pokeweed antiviral protein specifically inhibits Ty1-directed +1 ribosomal frameshifting and retrotransposition in Saccharomyces cerevisiae. J. Virol. 72, 1036-1042 (1998).

Dinman,J.D. & Kinzy,T.G. Translational misreading: mutations in translation elongation factor 1alpha differentially affect programmed ribosomal frameshifting and drug sensitivity. RNA. 3, 870-881 (1997).

Dinman,J.D., Ruiz-Echevarria,M.J., Czaplinski,K. & Peltz,S.W. Peptidyl-transferase inhibitors have antiviral properties by altering programmed -1 ribosomal frameshifting efficiencies: development of model systems. Proc. Natl. Acad. Sci. U. S. A 94, 6606-6611 (1997).

Cui,Y., Dinman,J.D. & Peltz,S.W. Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. EMBO J. 15, 5726-5736 (1996).

Dinman,J.D. Ribosomal frameshifting in yeast viruses. Yeast 11, 1115-1127 (1995).

Dinman,J.D. & Wickner,R.B. 5 S rRNA is involved in fidelity of translational reading frame. Genetics 141, 95-105 (1995).

Triteeraprapab,S. et al. Molecular cloning of a gene expressed during early embryonic development in Onchocerca volvulus. Mol. Biochem. Parasitol. 69, 161-171 (1995).

Balasundaram,D., Dinman,J.D., Tabor,C.W. & Tabor,H. SPE1 and SPE2: two essential genes in the biosynthesis of polyamines that modulate +1 ribosomal frameshifting in Saccharomyces cerevisiae.J. Bacteriol. 176, 7126-7128 (1994).

Vermut,M., Widner,W.R., Dinman,J.D. & Wickner,R.B. Sequence of MKT1, needed for propagation of M2 satellite dsRNA of the L- A virus of Saccharomyces cerevisiae. Yeast 10, 1477-1479 (1994).

Balasundaram,D., Dinman,J.D., Wickner,R.B., Tabor,C.W. & Tabor,H. Spermidine deficiency increases +1 ribosomal frameshifting efficiency and inhibits Ty1 retrotransposition in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A 91, 172-176 (1994).

Dinman,J.D. & Wickner,R.B. Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies. Genetics 136, 75-86 (1994).

Tercero,J.C., Dinman,J.D. & Wickner,R.B. Yeast MAK3 N-acetyltransferase recognizes the N-terminal four amino acids of the major coat protein (gag) of the L-A double-stranded RNA virus. J. Bacteriol. 175, 3192-3194 (1993).

Dinman,J.D. & Wickner,R.B. Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation. J. Virol. 66, 3669-3676 (1992).

Dinman,J.D., Icho,T. & Wickner,R.B. A -1 ribosomal frameshift in a double-stranded RNA virus of yeast forms a gag-pol fusion protein. Proc. Natl. Acad. Sci. U. S. A 88, 174-178 (1991).

Dinman,J.D. & Scott,A.L. Onchocerca volvulus: molecular cloning, primary structure, and expression of a microfilarial surface-associated antigen. Exp. Parasitol. 71, 176-188 (1990).

Scott,A.L., Dinman,J., Sussman,D.J., Yenbutr,P. & Ward,S. Major sperm protein genes from Onchocerca volvulus. Mol. Biochem. Parasitol. 36, 119-126 (1989).

Scott,A.L., Dinman,J., Sussman,D.J. & Ward,S. Major sperm protein and actin genes in free-living and parasitic nematodes. Parasitology 98 Pt 3, 471-478 (1989).

Huang,P.C., Morris,S., Dinman,J., Pine,R. & Smith,B. Role of metallothionein in detoxification and tolerance to transition metals. Experientia Suppl 52, 439-446 (1987).