
Publication List
Book Chapters
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Weng, Y., Ruiz-Echevarria, M.J., Zhang, S., Cui, Y., Czaplinski, K., Dinman, J.D.^ and Peltz, S.W.^ Characterization of the nonsense-mediated mRNA decay pathway and its effect on modulating translation termination and programmed frameshifting. In mRNA metabolism and post-transcriptional gene regulation. 1997 Wiley-Liss, Inc. pp.241-263.
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Dinman, J.D.^ and Dinman, B.D.^ The mode of absorption, distribution, and elimination of toxic materials. In Patty’s Industrial Hygiene and Toxicology, Fifth Edition, Volume 1, Part A. Harris, R.L. eds. 2000. John Wiley & Sons. pp. 41-87.
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Dinman, J.D.^ and Berry, M.J.^ 2007. Translational recoding in eukaryotes. In Translational Control in Biology and Medicine. Sonenberg, Hershey, and Matthews, eds. Cold Spring Harbor Laboratory Press. pp. 625 – 654.
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O’Connor, M.^ and Dinman J.D.^ 2010. Chapter 15: Host cell mutants affecting translational recoding. pp. 323 – 324. In RECODING: Violations of Decoding Dogma Enrich Gene Expression. Atkins, J.F. and Gesteland, R.F. eds. Springer.
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Dinman, J.D.* 2010. Chapter 5: Programmed -1 ribosomal frameshifting in SARS-CoV. In Molecular Biology of the SARS-Coronavirus. Lal, S.K. ed. Springer. pp. 63-72.
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Leshin, J.A.#, Meskauskas, A.# and Dinman, J.D.* 2012. Chapter 4: Structural analyses of the ribosome by chemical modification methods. In Biophysical Approaches to Translational Control of Gene Expression, Dinman, J.D. ed. Springer, New Yor
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Articles in Refereed Journals.
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Huang, P.C.*, Morris, S., Dinman, J.D., Pine, R. and Smith, B. 1987. Role of Metallothionein in Detoxification and Tolerance to Transition Metals. In Metallothionein II. Experimentia Supplementum 52:439-446. Birkhauser Verlag, Basel, Switzerland. PMID: 2959533
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Scott AL, Dinman J, Sussman DJ, Yenbutr P, Ward S.* 1989. Major sperm protein genes from Onchocerca volvulus. Mol. Biochem. Parasitol.. 36: 119 – 126. PMID: 2770787
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Scott, A.L., Dinman, J.D., Sussman, D.J. and Ward, S*. 1989. Major Sperm Protein and Actin Genes in Free-Living and Parasitic Nematodes. Parasitology 98:471-487. PMID: 2570394
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Dinman, J.D. and Scott, A.L.* 1990. Onchocerca volvulus: Molecular Cloning, Primary Structure and Expression of a Microfilarial Surface-Associated Antigen. Exp. Parasitol. 71:176-188. PMID: 1695577
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Dinman, J.D., Icho, T. and Wickner, R.B.* 1991. A -1 Ribosomal Frameshift in a Double-Stranded RNA Virus of Yeast forms a "Gag-pol" Fusion Protein. Proc. Natl. Acad. Sci. U.S.A. 88:174-178. PMCID: PMC50772
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Dinman, J.D. and Wickner, R.B. * 1992. Ribosomal Frameshifting Efficiency and gag/gag-pol Ratio are Critical for Yeast M1 Double-Stranded RNA Virus Propagation. Journal of Virology 66:3669-3676. PMCID: PMC241150
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Tercero, J.C., Dinman, J.D. and Wickner, R.B.* 1993. Yeast MAK3 N-Acetyltransferase Recognizes the N-terminal Four Amino Acids of the Major Coat Protein (gag) of the L-A dsRNA Virus. Journal of Bacteriology 175:3192-3194. PMCID: PMC204643
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Balasundaram, D., Dinman, J.D., Wickner, R.B., Tabor, C.W. and Tabor, H.* 1994. Spermidine Deficiency Increases +1 Ribosomal Frameshifting Efficiency and Inhibits Ty1 Retrotranspostion in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A.; 91:172-176. PMCID: PMC42908
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Dinman, J.D. and Wickner, R.B.* 1994. Translational maintenance of frame: Mutants of Saccharomyces cerevisiae with Altered -1 Ribosomal Frameshifting Efficiencies. Genetics; 136:75-86. PMCID: PMC1205794
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Vermut, M., Widner, W.R., Dinman, J.D. and Wickner, R.B*. 1994. Yeast Sequencing Reports: Sequence of MKT1, Needed for Propagation of M2 Satellite dsRNA of the L-A Virus of Saccharomyces cerevisiae. Yeast 10:1477. PMID: 7532890
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Balasundaram, D., Dinman, J.D., Tabor, C.W. and Tabor, H.* 1994. SPE1 and SPE2: Two Genes that Modulate +1 Ribosomal frameshifting Efficiency in Saccharomyces cerevisiae. Journal of Bacteriology 176:7126-7128. PMCID: PMC197094
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Triteeraprapab, S., Richie, T.L., Tuan, R.S., Shepley, K.J., Dinman, J.D., Neubert, T.S. and Scott. A.L.* 1995. Molecular Cloning of a Gene Expressed During Early Embryonic Development in Onchocerca volvulus. Molecular and Biochemical Parasitology 69:161-171. PMID: 7770081
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Dinman, J.D. and Wickner, R.B.* 1995. 5S rRNA is Involved in Fidelity of Translational Reading Frame. Genetics 141:95-105. PMCID: PMC1206744
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Cui, Y., Dinman, J.D. and Peltz, S.W.* 1996. mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. EMBO J. 15:5726-5736. PMCID: PMC452316
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Dinman, J.D.* 1995. Ribosomal Frameshifting in Yeast Viruses. Yeast 11:1115-1127. PMCID: PMC7169727 Invited Review Article
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Cui, Y., Dinman, J.D. and Peltz, S.W.* mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. 1996. EMBO J. 15: 5726-5736. PMCID: PMC452316
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Dinman, J.D.*, Ruiz-Echevarria, M.J., Czaplinski, K., and Peltz, S.W. 1997. Peptidyl transferase inhibitors have antiviral properties by altering programmed -1 ribosomal frameshifting efficiencies: development of model systems. Proc. Natl. Acad. Sci. USA 94:6606-6611. PMCID: PMC21205
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Dinman, J.D.^ and Kinzy, T.G.^ 1997. Translational misreading: mutations in translation elongation factor 1 differentially affect programmed ribosomal frameshifting and drug sensitivity. RNA 3:870-881. PMCID: PMC1369532
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Tumer, N., Parikh, B.A.#, Li, P.,and Dinman, J.D.* 1998. Pokeweed Antiviral Protein Specifically Inhibits Ty1-Directed +1 Ribosomal Frameshifting and Retrotranspostion in Saccharomyces cerevisiae. J. Virol. 72:1036-1042. PMCID: PMC124575
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Cui, Y., Dinman, J.D., Kinzy, T.G. and Peltz, S.W.* 1998. The Mof2/Sui1 Protein is a General Monitor of Translational Accuracy. Mol. Cell. Biol. 18: 1506-1516. PMCID: PMC108865
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Ruiz-Echevarria, M.J., Yasenchak, J.M.#, Han, X., Dinman, J.D., and Peltz, S.W.* 1998. The Upf3 protein is a component of the surveillance complex that monitors both translational and mRNA turnover and affects viral maintenance. Proc. Natl. Acad. Sci. USA 95:8721-8726. PMCID: PMC21143
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Dinman, J.D.*, Ruiz-Echevarria, M.J. and Peltz, S.W. 1998. Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents. Trends in Biotech. 16:190-196. PMCID: PMC7127214. Invited Review Article. Featured as journal cover artwork.
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Peltz, S.W., Hammell, A.B.# ,Cui, Y., Yasenchak, J.M.#, Puljanowski, L#. and Dinman, J.D.* 1999. Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol. Cell. Biol. 19:384-391. PMCID: PMC83896
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Hudak, K.A., Dinman, J.D. and Tumer, N.E*. 1999. Pokeweed antiviral protein accesses ribosomes by binding to L3. J. Biol. Chem. 274:3859-3864. PMID: 9920941
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Hammell, A.B.#, Taylor, R.L., Peltz, S.W., and Dinman, J.D.* 1999. Identification of putative programmed -1 ribosomal frameshift signals in large DNA databases. Genome Res. 9:417-427. PMCID: PMC310776
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Sheikh, M.S., Fernandez-Salas, E., Yu, M., Hussain, A., Dinman, Peltz, S.W., J.D. Huang, Y., Yuspa, S.H. and Fornace, A.J. Jr.* 1999. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes a putative translation factor. J. Biol. Chem. 274:16487-16493. PMID: 10347211
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Ciu, Y., Gonzalez, C.I., Kinzy, T.G., Dinman, J.D. and Peltz, S.W.* 1999. Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay. RNA. 5:794-804. PMCID: PMC1369805
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Liermann, R.T., Dinman, J.D., Sylvers, L.A. and Jackson, J.C.* 2000. Improved purification of the double stranded RNA from killer strains of yeast. BioTechniques. 28:64-65. PMID: 10649772
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Lopinski, J., Dinman, J.D. and Bruenn, J.A.* 2000. Kinetics of ribosomal pausing during programmed -1 translational frameshifting. Mol.Cell. Biol. 20:1095-1103. PMCID: PMC85227
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Dinman, J.D., Ruiz-Echevarria, M., Wang, W. and Peltz, S.W.* 2000. The case for the involvement of the surveillance complex in programmed -1 ribosomal frameshifting. RNA 6:1685 – 1686. PMCID: PMC1370036
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Hudak, K., Hammell, A.B.#, Yasenchak, J.#, Tumer, N.E., and Dinman, J.D.* 2001. A C-terminal deletion mutant of pokeweed antiviral protein inhibits programmed +1 ribosomal frameshifting without depurinating the sarcin/ricin loop. Virology 279:292-301. PMID: 11145910
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Harger, J.#, Meskauskas, A.#, Nielsen, J., Justice M.C., Dinman, J.D.* 2001. Ty1 retrotransposition and programmed +1 ribosomal frameshifting require the integrity of the protein synthetic translocation step. Virology 286:216-224. PMID: 11448174
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Meskauskas, A.# and Dinman, J.D.* 2001.Yeast ribosomal protein L5 anchors peptidyl-tRNA to the P-site. RNA 7:1084-1096. PMCID: PMC1307509
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Smith, M.W., Meskauskas, A., Wang, P., Sergiev, P.V., and Dinman, J.D.* 2001. Global mutagenesis of 5S rRNA in Saccharomyces cerevisiae. Mol Cell. Biol. 21: 8264 – 8275. PMCID: PMC99992
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Dinman, J.D., Richter, S., Plant, E.P., Taylor, R., Hammell, A.B., and Rana, T.M. 2002. The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure. Proc. Natl. Acad. Sci. USA 99: 5331-5336. PMCID: PMC122769
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Kinzy, T.G., Harger, J.#, Schmit, A.C., Justice, M.C., and Dinman, J.D.* 2002. New targets for antivirals: the ribosomal A-site and the factors that interact with it. Virology 300: 60 – 70. PMID: 12202206
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Harger, J.W.#, Meskauskas, A.#, and Dinman, J.D.* 2002. An ‘Integrated Model’ of programmed ribosomal frameshifting and post-transcriptional surveillance. TiBS 27: 448 – 454. PMID: 12217519. Invited Review Article. Featured as journal cover artwork.
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Plant, E.P.#, Muldoon Jacobs, K.L.#, Harger, J.W.#, Meskauskas, A.#, Jacobs, J.L.#, Baxter, J.L.#, Petrov, A.N.#, and Dinman, J.D.* 2003. The 9Å solution: how mRNA pseudoknots promote efficient programmed –1 ribosomal frameshifting. RNA 9:168-174. PMCID: PMC1237042
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Meskauskas, A.#, Baxter, J.L.#, Carr, E.A.#, Yasenchak, J.#, Gallagher, J.E.G., Baserga, S.J., and Dinman, J.D.* 2003. Delayed rRNA processing results in significant ribosome biogenesis and functional defects. Mol. Cell. Biol. 23:1602-1613. PMCID: PMC151716
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Meskauskas, A.#, Harger, J.W.#, Muldoon Jacobs, K.L.#, and Dinman, J.D.* 2003. Decreased peptidyltransferase activity correlates with increased programmed –1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae. RNA 9: 982-992. PMCID: PMC1240118
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Harger, J.W.# and Dinman, J.D.* 2003. An in vivo dual-luciferase system for studying translational recoding in the yeast Saccharomyces cerevisiae. RNA 9:1019-1024. PMCID: PMC1236998
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Plant, E.P.#, Wang, P.#, Jacobs, J. L.#, and Dinman, J.D.* 2004. A programmed -1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element. Nucleic Acids Research 32:784-790. PMCID: PMC373365
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Petrov, A.#, Meskauskas, A.#, and Dinman, J.D.* 2004. Ribosomal protein L3: influence on ribosome structure and function. RNA Biology, 1: 59-65. PMCID: PMC1989672
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Harger, J.W.# and Dinman, J.D.* 2004. Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough. RNA 10:1721-1729. PMCID: PMC1236997
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Jacobs, J.L.# and Dinman, J.D.* 2004. Systematic analysis of bicistronic reporter assay data. Nucleic Acids Research 32:e160-70. PMCID: PMC534638
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Plant, E.P#. and Dinman, J.D.* 2005. Torsional restraint: a new twist on frameshifting pseudoknots. Nucleic Acids Research, 33:1825-33. PMCID: PMC1072802
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Plant, E.P#., Perez-Alvarado, G, Jacobs, J.L#., Mukhopadhyay, B.#, Hennig, M., and Dinman, J.D.* 2005. A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal. PLoS Biology, 3:1012-1023. PMCID: PMC1110908
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Kipirasov, S.#, Petrov, A.#, Meskauskas, A.#, Sergiev, P.V., Dontsova, O.A., and Dinman, J.D.* 2005. Structural and functional analysis of 5S rRNA. Molecular Genetics and Genomics, 274: 235-247. PMCID: PMC1276653
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Meskauskas, A.#, and Dinman, J.D.* 2005. Identification of functionally important amino acids of ribosomal protein L3 by saturation mutagenesis. Mol. Cell. Biol., 25: 10863-10874. PMCID: PMC1316954
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Dontsova, O.A. and Dinman, J.D.* 2005. 5S rRNA: Structure and function from head to toe. International Journal of Biomedical Science 1: 3-7. PMCID: PMC2131706. Invited Review Article
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Plant, E.P.# and Dinman, J.D.* 2006. Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems. RNA 12: 666 – 673. PMCID: PMC1421095
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Muldoon-Jacobs, K.L.# and Dinman, J.D.* 2006. Specific effects of ribosome-tethered chaperones on programmed -1 ribosomal frameshifting. Eukaryotic Cell 5: 762- 770. PMCID: PMC1459665
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Song, H., Baxter-Roshek, J.L.#, Dinman, J.D. and Vakharia, V.N. 2006. Efficient expression of the 15kDa form of infectious pancreatic necrosis virus VP5 by suppression of a UGA codon. Virus Research 122: 61-68. PMID: 16891025
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RakauskaitÄ—, R.#, and Dinman, J.D.* 2006. An arc of unpaired “hinge bases” facilitates information exchange among functional centers of the ribosome. Molecular and Cellular Biology 26: 8992 – 9002. PMCID: PMC1636827
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Dinman, J.D.* 2006. Programmed ribosomal frameshifting goes beyond viruses: Organisms from all three kingdoms use frameshifting to regulate gene expression, perhaps signaling a paradigm shift. Microbe. 1: 521 – 527. PMCID: PMC1885200. Invited Review Article.
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Dinman, J.D.* 2006. Effect of 3`-Azido-3`-Deoxythymidine (AZT) on Telomerase Activity and Proliferation of HO-8910 Cell Line of Ovarian Cancer. Int J Biomed Sci. 2: 41. PMCID: PMC3614564. Invited Review Article.
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Jacobs, J.L.#, Belew, A.T.#, RakauskaitÄ—, R.#, and Dinman, J.D.* 2007. Identification of functional, endogenous programmed -1 ribosomal frameshift signals in the genome of Saccharomyces cerevisiae. Nucleic Acids Res. 35:165-74. PMCID: PMC1802563
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Baxter-Roshek, J.L.#, Petrov, A.N.#, and Dinman, J.D.* 2007. Optimization of ribosome structure and function by rRNA base modification. PLoS ONE. 2: e174. PMCID: PMC1766470
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Meskauskas, A.#, and Dinman, J.D.* 2007. Ribosomal protein L3: gatekeeper to the A-site. 2007. Molecular Cell 25: 877 – 888. PMCID: PMC1858676
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Plant, E.P.#, Nguyen, P.#, Russ, J.R.#, Pittman, Y.R., Nguyen, T.#, Quesinberry J.T#., Kinzy, T.G., and Dinman, J.D.* 2007. Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae. PLoS ONE 2: e517. PMCID: PMC1885216
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Swatkoski, S., Gutierrez, P., Ginter, J., Petrov, A.#, Dinman, J.D., and Fenselau, C.* 2007. Integration of residue-specific acid cleavage into proteomic workflows. J. Proteome Res., 6: 4525-4527. PMID: 17902642
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Chaudhuri, S., Vyas, K., Kapssi, P., Komar, A.A., Dinman, J.D., Barki, S., and Mazumder, B.* 2007. Human ribosomal protein L13a is Dispensable for Canonical Ribosome Function but Indispensable for Efficient rRNA Methylation. RNA 13: 2224-2237. PMCID: PMC2080596
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Swatkoski, S., Gutierrez, P., Ginter, J., Petrov, A.#, Dinman, J.D., and Fenselau, C.* 2008. Evaluation of Microwave-Accelerated Residue-Specific Acid Cleavage for Proteomic Applications. J. Proteome Res. 7: 579-586. PMID: 18189344
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RakauskaitÄ—, R.# and Dinman, J.D.* 2008. rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance. Nucleic Acids Res. 36: 1497 -1507. PMCID: PMC2275155
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Meskauskas, A.#, Russ, J.R.#, and Dinman, J.D.* 2008. Structure/function analysis of yeast ribosomal protein L2. Nucleic Acids Res. 36: 1826-1835. PMCID: PMC2330241
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Liao, P.-Y., Gupta, P., Petrov, A.N.#, Dinman, J.D. and Lee, K.H.* 2008. A new kinetic model reveals the synergistic effect of E-, P- and A-sites on +1 ribosomal frameshifting. Nucleic Acids Res 36: 2619-2629. PMCID: PMC2377451
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Belew, A.T.#, Hepler, N.L.#, Jacobs, J.L#. and Dinman, J.D.* 2008. PRFdb: A database of computationally predicted eukaryotic programmed -1 ribosomal frameshift signals. BMC Genomics 9: 339. PMCID: PMC2483730
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Stupina, V., Meskauskas, A.#, McCormack, J.C., Yingling, Y.G., Shapiro, B.A., Dinman, J.D., and Simon, A.E.* 2008. The 3’ proximal translational enhancer of turnip crinkle virus binds to 60S ribosomal subunits. RNA 14: 2394-2406. PMCID: PMC2578866
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Meskauskas, A.# and Dinman, J.D.* 2008. Ribosomal protein L3 functions as a 'rocker switch' to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea. Nucleic Acids Research 36: 6187-6198. PMCID: PMC2577335
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Petrov, A.N.#, Meskauskas, A.#, Roshwalb, S.C.#, and Dinman, J.D.* 2008. Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit. Nucleic Acids Research 36: 6187-6198. PMCID: PMC2577338
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Plant, E.P.# and Dinman, J.D.* 2008. The role of programmed -1 ribosomal frameshifting in coronavirus propagation. Frontiers in Bioscience: a Journal and Virtual Library. 13: 4873-81. PMCID: PMC2435135. Invited Review Article.
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Dinman, J.D.* 2009. The eukaryotic ribosome: current status and challenges. Journal of Biological Chemistry 284: 11761-11765. PMCID: PMC2673243. Invited Review Article. Profiled author in the May 1, 2009 issue. Artwork selected for the journal cover.
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Dinman, J.D.^ and Kinzy, T.G.^ 2009. Expanding the ribosomal universe. Structure 17: 1547 – 1548. PMCID: PMC2801869. Invited Preview Article.
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Plant, E.P.#, RakauskaitÄ—, R.#, Taylor, D. R., and Dinman, J.D.* 2010. Achieving a Golden Mean: Mechanisms by Which Coronaviruses Ensure Synthesis of the Correct Stoichiometric Ratios of Viral Proteins. J. Virol. 84: 4330-4340. PMCID: PMC2863758. Selected by the editors of the Journal of Virology for inclusion in "Spotlight", a feature in the Journal that highlights especially meritorious research articles of significant interest. Chosen as one of 4 publications highlighted as a “Research Breakthrough” by the University of Maryland Division of Research press release, April, 2010.
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Leshin, J.A.#, RakauskaitÄ—, R.#, Dinman, J.D.*, and Meskauskas, A. 2010. Enhanced purity, activity and structural integrity of yeast ribosomes purified using a general chromatographic method. RNA Biology 7: 354-360. PMCID: PMC4118464
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Meskauskas, A.#, and Dinman, J.D.* 2010. A molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-site. Nucleic Acids Research 38: 7800-7813. PMCID: PMC2995063
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Rhodin, M.H.J.# and Dinman, J.D.* 2010. A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding. Nucleic Acids Research, 38: 8377 – 8389. PMCID: PMC3001080. Selected by the editors of Nucleic Acids Research as a “Featured Article”, representing the top 5% of NAR papers in terms of originality, significance and scientific excellence.
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Liao, P.-Y., Choi, Y.S., Dinman, J.D., and Lee, K.H. 2011.* The many paths to frameshifting: kinetic modeling and analysis of the effects of different elongation steps on programmed –1 ribosomal frameshifting. Nucleic Acids Research 39: 300-312. PMCID: PMC3017607
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Belew, A.T.#, Advani, V.M.#, and Dinman, J.D.* 2011. Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast. Nucleic Acids Research 39: 2799-2808. PMCID: PMC3074144.
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Selected by the editors of Nucleic Acids Research as a “Featured Article”, representing the top 5% of NAR papers in terms of originality, significance and scientific excellence.
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Stupina, V.A., Yuan, S., Meskauskas, A.#, Dinman, J.D. and Simon, A.E. 2011. Ribosome binding to a 5’ translational enhancer is altered in the presence of the 3’UTR in cap-independent translation of Turnip crinkle virus. J. Virology 85: 4638-4653. PMCID: PMC3126203
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Selected by the editors of the Journal of Virology for inclusion in "Spotlight", a feature in the Journal that highlights especially meritorious research articles of significant interest.
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RakauskaitÄ—, R.#, and Dinman, J.D.* 2011. Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes. RNA 17: 855-854. PMCID: PMC3078735.
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Leshin, J.A.#, Heselpoth, R.#, Belew, A.T.#, and Dinman, J.D.* 2011. High throughput structural analysis of yeast ribosomes using hSHAPE. RNA Biology 8: 478-487. PMCID: PMC3360075
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Rhodin, M.H.J.# and Dinman, J.D.* 2011. The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity. Molecular Genetics and Genomics 285: 505-516. PMCID: PMC4106707.
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Rhodin, M.H.J.# and Dinman, J.D.* 2011. An Extensive Network of Information Flow through the B1b/c Intersubunit Bridge of the Yeast Ribosome. PLoS One 6: e20048. PMCID: PMC3098278
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RakauskaitÄ—, R.#, Liao, P.-Y., Rhodin, M.H.J.#, Lee, K. and Dinman, J.D.* 2011. A rapid, inexpensive yeast-based dual-fluorescence assay of programmed -1 ribosomal frameshifting for high throughput screening. Nucleic Acids Research 39: e97. PMCID: PMC3152369.
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Guo, R., Meskauskas, A.#, Dinman, J.D. and Simon, A.E.* 2011. Evolution of a helper virus-derived, ribosome binding translational enhancer in an untranslated satellite RNA of Turnip crinkle Virus. Virology 419: 10-16. PMCID: PMC3176665
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Jack, K.#, Bellodi, C., Landry, D.M., Niederer, R.#, Meskauskas, A.#, Musalgaonkar, S.#, Kopmar, N., Krasnykh. O., Dean, A.M., Thompson, S.R., Ruggero, D., and Dinman, J.D.* 2011. rRNA Pseudouridylation Defects Affect Ribosomal Ligand Binding and Translational Fidelity from Yeast to Human Cells. Molecular Cell 44: 660-666. PMCID: PMC3222873
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Meskauskas, A.#, Leshin, J.A.# and Dinman, J.D.* 2011. Chromatographic purification of highly active yeast ribosomes. J. Vis. Exp. 56: e3214 PMCID: PMC3227209. Invited Review Article.
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Ishimaru, D., Plant, E.P.#, Sims, A, Yount, B., Roth, B., Eldho, N., Pérez-Alvarado, G., Armbruster, D., Baric, R., Dinman, J.D., Taylor, D, and Hennig, M.* 2013. RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus. Nucleic Acids Res. 41:2594-608. PMCID: PMC3575852
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Dinman, J.D.* 2012. Control of gene expression by translational recoding. Adv. Protein Chem. Struct. Biol. 86: 129-149. PMCID: PMC7149833. Invited Review Article.
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Dinman , J.D.* 2012. Mechanisms and implications of programmed translational frameshifting. WIRES-RNA 3: 661-673. PMCID: PMC3419312. Invited Review Article.
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Jenner, L., Melnikov, S., Garreay de Lobresse, N., Ben-Shem, A., Iskakova, M., Meskauskas, A.#, Dinman, J.D., Yusupova, G., and Yusupov, M.* 2012. Crystal structure of the 80S yeast ribosome. Curr. Opin. Struct. Biol. 22: 1-12. PMID: 22884264. Invited Review Article.
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Plant, E.P.#, Sims, A., Baric, R., Dinman, J. and Taylor, D.* 2013. Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA production. Viruses 5: 279-294. PMCID: PMC3564121
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Advani, V.M.#, Belew, A.T.# and Dinman, J.D.* 2013. Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway. Translation 1: 38-47. Featured in the “Landes Highlights” section of RNA Biology, 10: 907. PMCID: PMC3908577
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Gao, F., Gulay, S.#, Kasprzak, W., Dinman, J.D., Shapiro, B.A., Simon, A.E.* 2013. The kissing-loop T-shaped structure translational enhancer of Pea enation mosaic virus can bind simultaneously to ribosomes and a 5' proximal hairpin. J. Virology 87:11987-12002. PMCID: PMC3807929
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Sulima, S.O.#, Gulay, S.#, Anjos, M., Patchett, S., Meskauskas, A.#, Johnson, A.W. and Dinman, J.D.* 2014. Eukaryotic rpL10 drives ribosomal rotation. Nucleic Acids Research 42: 2049-2063. PMCID: PMC3919601
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Ban, N., Beckmann, R., Cate, J.H.D., Dinman, J.D., Ellis, S.R., Lafontaine, D.L.J., Lindahl, L., Liljas, A., McAlear, M.S., Moore, P.B., Noller, H.F., Ortega, J., Panse, V.G., Ramakrishnan, V., Spahn, C.M.T., Steitz, T.A., Tchorzewski, M., Tollervey, D., Warren, A.J., Williamson, J.R., Wilson, D., Yonath, A., and Yusupov, M.* 2014. A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol.24: 165-169. PMCID: PMC4358319. Invited Review Article.
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de Messieres, M., Chang, J.-C., Belew, A.T.#, Meskauskas, A.#, Dinman, J.D., and La Porta, A. 2014. Single-molecule measurements of the CCR5 mRNA unfolding pathways. Biophysical J. 106: 244-252. PMCID: PMC3907219
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Sulima, S.O.#, Patchett, S., Advani, V.M.#, de Keersmaecker, K, Johnson, A. W. and Dinman J.D.* 2014. Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis. Proc. Natl. Acad. Sci. USA 111: 5640–5645. PMCID: PMC3992666
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Belew, A.T.#, Meskauskas, A.#, Musalgaonkar, S.#, Advani, V.#, Sulima, S.O.#, Kasprzak, W., Shapiro, B.A. and Dinman, J.D.* 2014. Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and NMD. Nature 251: 265 – 269. PMCID: PMC4369343
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Musalgaonkar, S.#, Moomau, C.# and Dinman, J.D.* 2014. Ribosomes in the balance: structural equilibrium ensures translational fidelity and proper gene expression. Nucleic Acids Research 42: 13384-92. PMCID: PMC4245932.
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Dashti, A., Schwander, P., Langlois, R., Fung, R., Li, W., Hossinizadeh, A., Liao, H., Pallesen, J., Sharma, G., Stupina, V.A., Simon, A.E., Dinman, J.D., Frank, J., and Ourmazd, A.* 2014. Trajectories of the ribosome as a Brownian nanomachine. Proc. Natl. Acad. Sci. USA 111: 17492-7. PMCID: PMC2673243
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Madsen, C., Hooper, I., Lundberg, L., Shafagati, N., Johnson, A., Senina, S., de la Fuente, C., Hoover, L.I., Fredricksen, B.L., Dinman, J.D., Jacobs, J., and Khen-Hall, K.* 2014. Small molecule inhibitors of Ago2 decrease Venezuelan Equine Encephalitis virus replication. Antiviral Research 112: 26-37. PMID: 25448087.
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Dinman, J.D.* 2015. Entry signals control development. Nature 517: 24-25. Invited News & Views article. PMCID: PMC4358788
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Belew, A.T.# and Dinman, J.D.* 2015. Cell cycle control (and more!) by programmed -1 ribosomal frameshifting: implications for disease and therapeutics. Cell Cycle 14: 172-178. PMCID: PMC4615106. Invited Review Article.
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de Keersmaecker, K. Sulima, S.O.#, and Dinman, J.D.* 2015. Ribosomopathies and the paradox of cellular hypo- to hyperproliferation. Blood 125:1377-1382. PMCID: PMC4342353. Invited Review Article.
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Advani, V. M.# and Dinman, J.D.*. 2015. "Reprogramming the genetic code: the emerging role of ribosomal frameshifting in regulating cellular gene expression". Bioessays 38: 21-26. PMCID: PMC4749135. Invited Review Article.
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Cheek, A. M.#, Musalgaonkar, S.#, Moomau, C.A.#, Gulay, S.P.#, Mirvis, M.#, and Dinman, J.D*. 2016. Ribosomal protein uS19 mutants reveal its role in coordinating ribosome structure and function. Translation 3: e1117703. PMCID: PMC4721500
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Baer, A., Lundberg, L., Swales, D., Waybright, N., Pinkham, C., Dinman, J.D., Jacobs, J.L., and Kehn-Hall, K.* 2016. Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. J. Virology 90: 3558-3572. PMCID: PMC4794670
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Dinman, J.D.* 2016. Pathways to specialized ribosomes: the Brussels Lecture. J. Mol. Biol. 428: 2186-2194. PMCID: PMC4884523. Invited Review Article.
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Mailliot, J. Garreau de Loubresse, N., Yusupova, G., Meskauskas, A., Dinman, J.D., and Yusupov, M.* 2016. Crystal structures of the uL3 mutant ribosome: illustration of the importance of ribosomal proteins for translation efficiency. J. Mol. Biol. 428:2195-202. PMCID: PMC5331904
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Tamm, T.*, Kisly, I., Gulay, S.P., Mäeorg, U., Dinman, J.D., and Remme, J. 2016. The functional role of eL19 and eB12 intersubunit bridge in the eukaryotic ribosome. J. Mol. Biol. 428:2203-16. PMCID: PMC4884501.
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Moomau, C.#, Musalgoankar, S.#, Khan, Y.A.#, Jones, J.E.# and Dinman, J.D.* 2016. Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA Elements. Journal of Biological Chemistry 291: 15788-15795. PMCID: PMC4957060
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Kendra, J.A.#, de la Fuente, C., Brahms, A., Woodson, C., Bell, T.M., Chen, B.#, Khan, Y.A.#, Jacobs, J.L., Kehn-Hall, K. and Dinman, J.D.*. 2017. Ablation of programmed -1 ribosomal frameshifting in Venezuelan equine encephalitis virus results in attenuated neuropathogenicity. J. Virol. 91: e01766-16. PMCID: PMC5244343. Selected by the editors of the Journal of Virology for inclusion in "Spotlight," a feature in the Journal that highlights research articles of significant interest. Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Joel Baines.
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Meydan, S., Llepacki, D., Karthikeyan, S., Margus, TL, Thomas, P., Jones, J.E.#, Khan, Y.A.#, Briggs, J.W.#, Dinman, J.D., Vazquez-Laslop, N. and Mankin, A.S. 2017. Programmed ribosomal frameshifting generates a copper transporter and a copper chaperone from the same gene. Molecular Cell 65: 207-219. PMCID: PMC5270581. Selected as the “Featured Article” by the editors of Molecular Cell.
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Paolini, N.A., Attwood, M., Sondalle, S.B., Marques dos Santos Vieira, C.#, van Adrichem, A.M., di Summa, F.M., O-Donohue, M.-F., Gleizes, P.-E., Rachuri, S.#, Briggs, J.W.#, Fischer, R., Ratcliffe, P.J., Wlodarski., M.W., Houtkooper, R.H., von Lindern, M., Kuijpers, T.W., Dinman, J.D., Baserga, S.J., Cockman, M.E., and MacInnes, A.W.* 2017. A novel ribosomopathy reveals decoding defective ribosomes driving human dysmorphism. The American Journal of Human Genetics 100:506-522. PMCID: PMC5339345
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Gulay, S.P.#, Bista, S., Varshney, A., Kirmizialtin, S., Sanbonmatsu, K.Y., and Dinman, J.D.* 2017. Tracking fluctuation hotspots on the yeast ribosome through the elongation cycle. Nucleic Acids Research 45: 4958 – 4971. PMCID: PMC5416885.
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Briggs, J.W.# and Dinman, J.D.* 2017. Subtractional heterogeneity: a crucial step toward defining specialized ribosomes. Molecular Cell 76: 3-4. PMCID: PMC5828171. Invited Preview Article.
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Sulima, S.O.#, Hofman, I.J., De Keersmaecker, K., and Dinman, J.D.* 2017. How ribosomes translate cancer. Cancer Discovery. 7:1069-1087. PMCID: PMC5630089. Invited Review Article.
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Briggs, J.W.#, Ren, L., Chakrabarti, K.R., Tsai, Y.C., Weissman, A.M., Hansen, R., Gustafson, D., Khan, Y.A.#, Dinman, J.D. and Khanna, C. 2017. Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus. PLoS ONE 12:e0185089. PMCID: PMC5605117
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Girardi, T., Sulima, S.O., Vereecke, S., Khan, Yl, Francello, L., Dirkx, E., Flickinger, Z.#, Schwag, C., Op de Beeck, J, Verbeeeck, J., Royaert, J., Geerdens, E., Vincente, C., Bornschein, S., Harrison, C.J., Meijerink, J. P., Cools, J., Dinman, J.D., Kampen, K.R., and De Keersmaecker, K. 2018. The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. Leukemia 32: 809-818. PMCID: PMC5669462
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Chen, B.#, Longhini,A.P., Nußbaumer, F., Kreutz, C., Dinman, J. and Daye, T.K. 2018. CCR5 RNA Pseudoknots: Residue and site-specific Labeling correlate internal motions with microRNA binding. Chemistry 24:5462-5468. PMCID: PMC7640883.
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Kendra, J.A.#, Advani, V.M.#, Chen, B.#, Briggs, J.W.#, Zhu, J.#, Bress, H.J.#, Pathy, S.M.#, and Dinman, J.D.* 2018. Functional and structural characterization of the Chikungunya virus translational recoding signals. J Biol Chem. 293:17536-17545. PMCID: PMC6231143
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Dinman, J.D.* Shapeshifting RNAs guide innate immunity. 2018. J Biol. Chem. 293:16125-16126. PMCID: PMC6187635. Invited Commentary for JBC Editors Pick series.
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Dever, T., Dinman, J.D., and Green, R. 2018. Translation Elongation, Recoding, and Quality Control in Eukaryotes. In: Translational Control in Biology and Medicine. Sonenberg, Hershey, and Matthews, eds. Cold Spring Harbor Laboratory Press. PMCID: PMC6071482. Invited review article
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Sulima, S.O., Kampen, K.R., Vereecke, S., Verbeeck, J., Dinman, J.D. and De Keersmaecker, K. Ribosomal lesions as promoters of oncogenic mutagenesis. 2019. Cancer Research 79: 320-327. PMCID: PMC7116100. Featured as a “Priority Report”. Artwork featured on the cover of the journal issue.
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Haag, E.S. and Dinman, J.D.* 2019. Still searching for specialized ribosomes. 2019. Developmental Cell. 48: 744-746. PMID: 30913404. Invited Preview article. Featured in CMNS News & Events https://cmns.umd.edu/news-events/features/4384
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Dinman, J.D.* 2019. Scaring ribosomes shiftless. 2019. Biochemistry. 58: 1831-1832. PMCID: PMC6765253. Invited Viewpoint article
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Dinman, J.D.* 2019. Translational recoding signals: expanding the synthetic biology toolbox. J. Biol. Chem. 294: 7537-7545. PMCID:PMC6514632. Invited Review article
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Dinman, J.D.* 2019. Slippery ribosomes prefer shapeshifting mRNAs. Proceedings of the National Academy of Sciences USA. 116: 19225-19227. PMCID: PMC6765253. Invited Commentary
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Sulima, S.O. and Dinman, J.D.* 2019. The expanding riboverse. Cells 8: 1205. PMCID: PMC6829380. Invited Review article.
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Dahal, B., Lin, S.-C., Carey, B., Jacobs, J., Dinman, J.D., van Hoek, M., Adams, A., Kehn-Hall, K. 2020. EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death. Virology 539:121-128. PMCID: PMC7126400
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Lezzerini, M., Saby, M., O'Donohue, M.-F., Marques dos Santos Vieira, C. #, Penzo, M., Elfrink, H., Diets, I., Gastou, M., Nin-Velez, A., Nikkels, P., Olson, A. #, Zonneveld-Huijssoon, E., Jongmans, M., Zhang, G., van Weeghel, M., Houtkooper, R., Wlodarski, M., Kuiper, R., Bierings, M., van der Werff ten Bosch, J., Leblanc, T., Montanaro, L., Dinman, J., Gleizes, P.-E., Da Costa, L., MacInnes, A. 2020. Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism. Nucleic Acids Research. 48: 770-787. PMCID: PMC6954397
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Kelly, J.A. #, Olson, A.N. #, Neupane, K., Munshi, S., San Emeterio, J., Pollack, L., Woodside, M.T. and Dinman, J.D.* 2020. Structural and functional conservation of the programmed− 1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2). J. Biol. Chem. 295:10741-10748. PMCID: PMC7397099. Recommended by Faculty Opinions (formerly the Faculty of 1000) as being of special significance in its field by Faculty member Thomas Wollert.
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Olson, A.N, and Dinman, J.D. 2020. Two ribosomes are better than one (sometimes). Molecular Cell. 79:541-543. PMID: 32822579. Invited Preview
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Nabais Sa, M.J., Olson, A.N.#, Azorin, F.M., Quijada-Fraile, P., Yoon, G., Nommo, G., Bomez, C.M., Willemsen, M.A., Schneider, A.#, Pfundt, R., de Brower, A.P.M., Dinman, J,D.*, and deVries, B.B.A.* 2021. De Novo variants in EEF2 cause a neurodevelopmental disorder with structural brain anomalies. Human Molecular Genetics. 29:3892-3899. PMCID: PMC7907856
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Kelly, J.A # and Dinman, J.D.* Programmed -1 Ribosomal Frameshifting in Coronaviruses: A Therapeutic Target. Virology 554: 75-82. PMCID: PMC7833279
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Dahal, B., Lehman, C.W., Akhrymuk, I., Bracci, N.R., Panny, L., Barrera, M.S., Bhalla, N., Jacobs, J.L., Dinman, J.D. and Kehn-Hall, K. 2021. PERK is critical for alphavirus nonstructural protein translation. Viruses 13: 892-908. PMCID: PMC8151226
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Munshi, S., Neupane, K., Ileperuma, S,M., Halma, M.T.J., Kelly, J.A.#, Halpern, C.F.#, Dinman, J.D.*, Loerch, S.*, and Woodside, M.T.* 2022. Small-molecule ligands can inhibit− 1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses. Viruses, 14: 177. PMCID: PMC8876150
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Lehman, C.W., Smith, A, Kelly, JA.#, Jacobs, J.L., Dinman, J.D., and Kehn-Hall, K. 2022. EGR1 upregulation during encephalitic viral infections contributes to inflammation and cell death. Viruses 14: 1210. PMCID: PMC9227295
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Barna, M., Karbstein, K., Tollervey, D., Ruggero, D., Brar, G., Greer, E., and Dinman, J.D. The promises and pitfalls of specialized ribosomes. 2022. Molecular Cell 82: 2179-2184. PMCID: PMC10747187. Invited “Voices” review on Ribosome Heterogeneity for the 25th anniversary special focus issue of Molecular Cell.
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Meydan S, Klepacki D, Karthikeyan S, Margus T, Thomas P, Jones JE, Khan YA, Briggs J, Dinman JD, Vázquez-Laslop N, Mankin AS. Response to: Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding. 2022. Molecular Cell 82: 3523. doi: 10.1016/j.molcel.2022.08.025.
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Rolband, L., Beasock, D., Wang, Y., Shu, Y.-G., Dinman, J.D., Schlick, T., Zhou, Y., Kieft, J.S., Chen, S.-J., Bussi, G., Oukhaled, A., Gao, X., Sulc, P., Binzel, D., Bhullar, A.S., Liang, C., Guo, P. and Afonin, K. 2022. Third Conference on Biomotors, Viral Assembly, and RNA Nanobiotechnology: Current Achievements and Future Directions. Computational and Structural Biotechnology Journal 20:6120-6137. PMCID: PMC9672130
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Olson, A.N. and Dinman, J.D. Deep mutational analysis of eEF2 residues implicated in human disease. 2023. J. Biol. Chem. 299:102771. PMCID: PMC9830224. Selected by the Editors of JBC as a “Recommended Read”.
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Rodregiez-Garcia, M.E., Cotrina-Vinagre, F.J., Sanchez-Calvin, M.T., Quijada-Fraile, P., Nabais Sa, J.J., Dinman, J.D., de Vries, B.B.A., and Martinez, Azorin, F. A novel de novo variant in the CASK gene cause a severe neurodevelopmental disorder that masks the phenotype of a new novel de novo variant in EEF2 gene. 2023. Journal of Human Genetics 68: 553-550. PMID: 37072624. doi: 10.1038/s10038-023-01150-4.
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Kelly, J.A. and Dinman, J.D. Shiftless Is a Novel Member of the Ribosome Stress Surveillance Machinery That Has Evolved to Play a Role in Innate Immunity and Cancer Surveillance. 2023. Viruses 15: 2296. PMCID: PMC10747187
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Loughran, G. Andreev, D.E., Terenin, I.M., Namy, O., Mikl, M., Yordanova, M.M., McManus, C.J., Firth, A.E., Atkins, J.F., Fraser, C.S., Ignatova, Z., Iwasaki, S., Kufel, J., Larson. O., Leidel1, S.A., Mankin, A.S., Mariotti, M., Tanenbaum, M.E., Topsirovic, I., Vázquez-Laslop, N., Gabriela Viero, Neva Caliskan, Yiwen Chen, Patricia L. Clark, Jonathan D. Dinman, Farabaugh, P.J., Gilbert, W.V., Green, R., Ivanov, P., Kieft, J.S., Muehlemann, O., Sachs, M., Shatsky, I.N., Sonenberg, N., Steckelberg, A.-L., Willis, A.E., Woodside, M.T., Valasek, L.S., Dmitriev, S.E., Baranov, P.V. 2025. Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR). 2025. Nature Structural & Molecular Biology. 32: 418-430. PMID: 40033152
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Chen, C.-W., Papadopoli, D., Szkop, K.J., Guan, B.-J., Alzahrani, M., Wu, J., Asraf, M.M., Krokowski, D., Vourekas, A., Merrick, W.C., Komar, A., Koromilas, A.E., Gorospe M., Payea, M.J., Wang, F., Schaffer, A., Miron, A., Bederman, I., Jankowsky, E., Vogel, C., Valášek, L.S., Dinman, J.D., Zhang Y., Tirosh B., Topisirovic, I., Larsson, O., and Hatzoglou, M. Plasticity of the Mammalian Integrated Stress Response. 2025. Nature. doi: 10.1038/s41586-025-08794-6. PMID: 40140574
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Shang, X., Galkin, A.G., Wang, Y., Jin, S., Chiang, C.-I., Dinman, J.D., Fuerst, T., Sajadi., M., Pozharskiy, E., and Li, Y. High-resolution Analysis of Potent and Broadly Neutralizing Antibodies from a Convalescent COVID-19 Patient Unveils Neutralizing Epitopes across SARS-CoV-2 Variants. (in preparation).
Invited Commentaries
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Commentary on “Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism” originally published in Scientific Reports on April 6, 2022. Published in ASM Connect, May 13, 2022.
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Dinman J: Faculty Opinions Recommendation of [Luan Y et al, Nucleic Acids Res 2022, Feb 08 DOI: 10.1093/nar/gkac053]. In Faculty Opinions, 08 Feb 2022; doi: 10.3410/f.741594409.793591522
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Dinman J: Faculty Opinions Recommendation of [Zimmer MM et al., Nat Commun 2021 12(1):7193]. In Faculty Opinions, 05 Jan 2022; doi: 10.3410/f.741303171.793590706
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Commentary on “SARS-CoV-2 protein ORF3a is pathogenic in Drosophila and causes phenotypes associated with COVID-19 post-viral syndrome” originally published in bioRxiv, Dec. 20,2020. Published in the ASM Covid-19 Research Registry, January 22, 2021.
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Dinman J: Faculty Opinions Recommendation of [Trainor BM et al., RNA 2021]. In Faculty Opinions, 29 Oct 2021; doi: 10.3410/f.740713491.793589199
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Commentary on “SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis” originally published in Nature, 12 May, 2021. Published in ASM Connect, June 3, 2021.
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Commentary on “SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response”, originally published in mBio, September 21, 2021. Published in ASM Connect, November 12, 2021.
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Dinman J: Faculty Opinions Recommendation of [Halma MTJ et al., Proc Natl Acad Sci USA 2019 116(39):19500-19505]. In Faculty Opinions, 17 Sep 2019; doi: 10.3410/f.736422789.793565059